Musicians have long been afflicted by diseases of the Crenolanib kidney, particularly nephrolithiasis, for which Marin Marais in 1725 composed a unique piece for the viol detailing the harrowing experience of cutting for stone.’ Beethoven and Mozart were afflicted by kidney disease, as are several current musicians. Where past musicians succumbed to their failing kidneys, the advent of

renal replacement therapy has given today’s musicians, such as James DePreist and Natalie Cole, the opportunity to continue performing and composing. Several notable physicians of old have excelled as musicians; one example is Jacob Henle (1809-1885), for whom the loop of Henle is named, another is Robert Christison, a contemporary of Richard Bright, who is considered a founder of nephrology’. Importantly, music therapy, as used in the times of Hippocrates and King David, has evolved from an empiric to a well-established scientific discipline. Given the recent enlarging body of scholarly studies of music therapy, its rudimentary role in nephrology deserves further exploration.”
“Background: The purpose of this study was to evaluate the efficacy and feasibility of carbon ion radiotherapy (CIRT) for oligo-recurrent lung tumors from colorectal cancer (CRC). Methods:

From May 1997 to October 2012, 34 consecutive patients with oligo-recurrent pulmonary metastases from CRC were treated with CIRT. The patients were not surgical candidates for medical GSK1210151A price reasons or patient refusal. Using a respiratory-gated technique, carbon ion therapy was delivered with curative intent using 4 coplanar beam angles. A median dose of 60 GyE (range, 44-64.8 GyE) was delivered to the planning target volume (PTV), with a median daily dose of 15 GyE (range, 3.6-44 GyE). Treatment outcome was analyzed in terms of local control rate (LCR), survival rate, and treatment-related Pinometostat complications.

Results: In total, 34 patients with 44 oligo-recurrent pulmonary lesions were treated with CIRT. Median follow-up period was 23.7 months. The 2- and 3-year actuarial LCRs of the treated patients were 85.4% +/- 6.2% and 85.4% +/- 6.2%, respectively. Overall survival was 65.1% +/- 9.5% at 2 years, and 50.1% +/- 10.5% at 3 years. Although survival rates were relatively worse in the subsets of patients aged smaller than 63 years or with early metastasis ( smaller than 36 months after resection of primary site), these factors were not significantly correlated with overall survival (P = 0.13 and 0.19, respectively). All treatment-related complications were self-limited, without any grade 3-5 toxicity. Conclusions: CIRT is one of the most effective nonsurgical treatments for colorectal lung metastases, which are relatively resistant to stereotactic body radiotherapy.